An Overview of Biological Macromolecule Crystallization
نویسندگان
چکیده
منابع مشابه
An Overview of Biological Macromolecule Crystallization
The elucidation of the three dimensional structure of biological macromolecules has provided an important contribution to our current understanding of many basic mechanisms involved in life processes. This enormous impact largely results from the ability of X-ray crystallography to provide accurate structural details at atomic resolution that are a prerequisite for a deeper insight on the way i...
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X-ray crystallography is the method of choice for determlning the 3-D structure of large macromolecules at a high enough resolution. The rate limiting step in structure determination is the crystallization itself. It takes anywhere between a few weeks to several years to obtain macromolecuiar crystals that yield good diffraction patterns. The theory of forces that promote and maintain crystal g...
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The NIST/NASA/CARB Biological Macromolecule studies requires not only finding suitable chemical agents Crystallization Database (BMCD) contains crystal data that induce and sustain crystal growth but also that those and crystallization conditions for biological parameters such as protein concentration, ionic strength, macromolecules abstracted from the literature. Each temperature, pH, etc., be...
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The protein structural entries grew far slower than the sequence entries. This is partly due to the bottleneck in obtaining diffraction quality protein crystals for structural determination using X-ray crystallography. The first step to achieve protein crystallization is to find out suitable chemical reagents. However, it is not an easy task. Exhausting trial and error tests of numerous combina...
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The NIST/NASA/CARB Biological Macromolecule Crystallization Database (BMCD), NIST Standard Reference Database 21, contains crystal data and crystallization conditions for biological macromolecules. The database entries include data abstracted from published crystallographic reports. Each entry consists of information describing the biological macromolecule crystallized and crystal data and the ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2013
ISSN: 1422-0067
DOI: 10.3390/ijms140611643